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Internal registration systems and tools are all based on HELM.
Novartis:
Novartis makes extensive use of HELM for nucleotide registration and analysis. The open-source HELM tools are integrated with the internal informatics landscape.
Yohann Potier said, “HELM allows Novartis to accurately describe its chemically-modified constructs using an industry standard for registration.”
Merck:
Merck has been slowly adopting the HELM notation across our Discovery Chemistry Modalities organization focusing first on simple linear peptides and oligonucleotides. Using the Pistoia HELM editor for creation, editing and registration of monomers and chemical modifiers, our Modalities chemists can now work confidently with their monomers across multiple environments including our biopolymer registration system, our BioviaDraw platform and our tools within Insight for Excel. In 2018 we anticipate incorporating complex, macrocyclic biopolymers into the HELM supported workflows, peptide metabolite identification support and antibody-peptide conjugates. All of this facilitated by the easy to use tools leveraging HELM notation as a foundation.
Novartis:
Novartis makes extensive use of HELM for nucleotide registration and analysis. The open-source HELM tools are integrated with the internal informatics landscape.
Yohann Potier said, “HELM allows Novartis to accurately describe its chemically-modified constructs using an industry standard for registration.”
Pfizer:
As the originators of the HELM standard, Pfizer has based their entire macromolecular registration infrastructure on HELM and its associated biomolecule toolkit.
Sergio Rotstein said, “While the enablement of biomolecular registration was already of great value to Pfizer, the establishment of HELM as an industry standard provided even greater value by facilitating cross-company interoperability and biomolecular data exchange, a very desirable outcome in our increasingly collaborative industry”
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