Versions Compared

Version Old Version 10 New Version 11
Changes made by

Vladimir Makarov

Vladimir Makarov

Saved on

Key

  • This line was added.
  • This line was removed.
  • Formatting was changed.

...

Description

Mitigation

Responsible Party

Failure to identify business questions, or picking too many or too few

Draft appropriate business questions

Lee Harland, John Wise, Bruce Press

Validate that Open Targets either has a ready to use Knowledge Graph implementation, or can be converted into a KG with reasonable cost

  • Technology research - review Open Targets

  • Review preliminary work done at Abbvie

  • If no KG is available, estimate the conversion process

    • If estimates indicate infeasibility, this may become a gap

    Meeting on Jan 17, 2024: recording (password: w*Qi2#D9) and transcript

    BioCypher could be the right KG. It contains Open Targets. Required steps are:

    • QC (anything missing?)

    • Update process

    • Learn about Abbvie prototypes

    The Hyve
    Jordan Ramsdell
    Robert Gill
    Brian Evarts

    Failure to identify a suitable LLM

    Technology research, feature and cost analysis, and selection

    Jon Stevens, Etzard Stolte, Helena Deus; Brian Evans

    Failure to download a large volume of data (all of the PubMed as a maximum) for the prompt-tuning of the LLM

    TBD

    Failure to perform KG generation from text by an LLM

    1. Technology research

    2. If no ready-to-use technology exists, estimate bespoke development (tuning an existing LLM for this purpose)

    Failure to perform local KG comparison with calculation of a score

    1. Technology research

    2. If no ready-to-use technology exists, estimate bespoke development

    3. If estimates indicate infeasibility, this may become a gap

    Failure to generate a proper query for a KG database system by an LLM

    Technology research. Code generation by LLMs is a common task, so this risk may be seen as low

    Failure to build a prototypical target discovery pipeline on the limited budget in case of mounting technical difficulties

    Schedule the project in phases. Aim to answer known unknowns and to establish risk mitigation strategies early in this phase (“project elaboration”)

    ...