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Vladimir Makarov

The innovation team: innovate@pistoiaalliance projectenquiries@pistoiaalliance.org

The Problem:

It is not possible to use AI and ML technologies without large volumes of high-quality data. While many projects to produce disease-specific data sets exist both in public and in private R&D, the same is not true for the healthy controls. Typically control data are only gathered in conjunction with the data gathering for the disease cases. The absolute number of healthy control cases are low and the coverage (by organ, tissue, and assay technology) may be insufficient. Quality of such control samples may also be in question, for instance, labeling tumor margin tissue as a healthy control. The reason for this situation is lack of incentive to invest in healthy control samples in the absence of investment in the disease-specific R&D. On the other hand, similarities between pharmaceutical research programs may result in duplication of effort for generation of healthy control data.

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