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The importance of the FAIR principles [Wilkinson et al. 2016] is well recognised amongst researchers in academia and industry, but its implementation is not yet mature in the clinical domain  [Kubben et al.  2019]. This guide aims to raise awareness of the value of FAIR clinical data. It is designed to facilitate pragmatic decision making based on FAIR clinical data and metadata management, which is addressed in Section 2 (Metadata). Topics such as data governance and additional facets of data management such as quality and training are presented in Section 3 (Application). The best practices in data management (“bottom-up”) and strategic data governance (“top-down”) are foundational for achieving a deeply integrated data-centric culture to serve communities of users and stakeholders in the life science industry.

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