The HELM Antibody Editor allows the user to visualise and manipulate antibody structures.
It includes many features, but the ability to detect domains and add structural features such as Cys-Cys bonds is central.
**New** HAbE2
HAbE2 was released to GitHub in January 2018. Many thanks again to Roche who have continued to develop the antibody editor and have donated their efforts to the open source community.
Key new features include:
MonomerDesigner: ADCDesigner Domain Protease Reaction Sortase Coupling Biotinylation Domain Protease Reaction Sortase Coupling Biotinylation |
The following documents provide an overview of the antibody editor and the functionality available.
HELM Antibody Editor: What is it, what can it do? (slides)
Extended Overview of HAbE (slides)
User guide for the HELM Antibody Editor (document)
All code is published in GitHub
HAbE2 : https://github.com/PistoiaHELM/HELMAntibodyEditor2
Example Plugins : https://github.com/PistoiaHELM/HELMAntibodyEditor2Plugin
How to connect to the domain / mutation / rule libraries when located in a database
Custom Master Libraries in HAbE v2.pdf
How to write plugins e.g. to store the antibody constructs in databases instead of XML files
How to write plugins for HAbE v2.pdf
HELM is an open source project released under the MIT license. However it currently has some dependencies on third party tools.
The HELM Toolkit requires MarvinBeans version 5.0 or higher from ChemAxon. A copy of the required library (MarvinBeans-5.0.jar) is included for your convenience. ChemAxon has graciously agreed to provide a royalty-free license for the utilization of MarvinBeans directly through the HELM editor and notation toolkit (specifically for operations pertaining to the chemical representation of HELM monomers and macromolecules.) Please contact Cassell Essell (cessell@chemaxon.com) to obtain this license. Utilization of the MarvinBeans library outside of the aforementioned scope and beyond a trial basis requires the procurement of a regular MarvinBeans license.
The project is actively working to remove these restrictions. We welcome anyone who wishes to contribute to the project by replacing any of these components.