Microbiome references

Documents and articles of interest to the team

	File	Modified
Labels No labels Preview View	PDF File TMC Microbriom Startup intro.pdf	Jun 07, 2018 by David Proudlock

References / Articles (weblink etc.)

Article	Notes / Comments
https://theconversation.com/gut-microbes-may-affect-heart-disease-risk-new-research-94552	(Christy)
	(Christy) Emma Allen Vercoe ("Poopy lab" expert TED talk
https://www.scientificamerican.com/article/a-trip-to-ldquo-the-poopy-lab-rdquo-in-the-interest-of-drug-development/	(Christy) Article on Emma Allen Vercoe and her "Poopy lab"
https://hmpdacc.org/	NIH Human Microbiome project, 2 projects: https://hmpdacc.org/hmp/ (5 major body site, using meta genomic shogun sequencing) https://hmpdacc.org/ihmp/ (three (pregnancy, IBS, type 2 diabetes onset) cohorts using multiple 'comics technologies)
https://labiotech.eu/microbiome-research-review/	Overview: where is microbiome heading in our industry? Themes: 800+ clinical trials in this space Market potential: $3.2Bn by 2024 Areas of focus Mapping microbial genes Oncology potential microbiome based therapeutics microbiota transplantation Drugs targeting microbiota Using bacteriophages CRISPR/Cas9 cuttign bacteria DNA Bioengineering bacteria to produce drugs in the gut What's on the horizon? Microbiome diagnostics / kits Start of pharma investment (e.g J&J and Vedanta Challenges: No established FDA protocols for the microbiome
https://www.nature.com/articles/d41586-018-05208-8	Influence of microbiota in stomach on whether a cancer drug will work or not. Examples: Merck: faecal microbiome transplant to see if can switch non-responders to a drug treatment to a successful outcome Challenges / Oportunities: "The researchers looked at people with cancer from France and the United States, so diet could account for some of the differences, Wargo says. But variations in sample collection, data analysis and statistical methods could also have skewed the results, says Joël Doré, a biologist at the French National Institute for Agricultural Research in Paris who in 2011 helped to launch the International Human Microbiome Standards (IHMS) project with the aim of improving data reproducibility in microbiome research." "Wargo says that the community should standardize its approaches for collecting samples and doing analyses, as well as for validating studies in larger groups of patients."
https://www.rdmag.com/news/2018/07/could-your-gut-microbes-hinder-your-cancer-treatment?et_cid=6411488&et_rid=928686399&type=headline&et_cid=6411488&et_rid=928686399&linkid=content	Fecal Microbiome Transplant clinical study to begin identifying gut microbiome profiles and their impact on resistance to cancer drug immunotherapies.

Contacts

Contact / Community

Notes

http://www.nofone.org/microbiome

(Christy) Autism research group (including Emma Allen Vercoe) one of their research areas is the microbiome as this page details.

The key point of this group is that they are trying to encourage and initiate more funding for studies in this area. So research is still limited.

http://www.translationalmicrobiome.org/

Translational Microbiome Research forum

http://www.microbiome-standards.org/

Standards group (EMBL included) - primarily universities

Organisations and their interest in this space

Organisation

Interest in microbiome

Texas Medical Center Biodesign see file in list above ( TMC Microbriom Startup intro.pdf)

(Christy) - “start-up” - got an intro to these guys through Tim Hoctor (who incidentally introduced them, I believe, to Alan Lewis). See attached document and at end list of folks/advisors.