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Biomolecule Toolkit and the macromolecule sketcher BioEddie are natively supporting the HELM standard. The tools provide capabilities for managing a centralized monomer library, registering and performing uniqueness checks of macromolecules, generating a HELM notation from small molecule representations and sequences, and representing modalities with partially or fully unknown chemical structures.
Roland Knispel, Project Lead for Biologics Informatics at ChemAxon, said, “Our HELM-based tools are helping our customers to manage chemically modified sequence-based modalities. A single environment for various types of modalities, improved data quality and utilizing an industry-wide standard for data exchange are the key benefits reported back to us by our users. By market demand our platform is now being integrated into solutions provided by IDBS and other partners.”
Dotmatics:
Dotmatics has adopted the Pistoia Alliance’s HELM notation as part of its biologics discovery suite. Dotmatics’ biological registration system, Bioregister, integrates the HELM Web Editor to create and edit sequences in HELM notation. Bioregister also generates, stores, and reads/writes HELM notation. This allows users to work with their HELM-defined entities within the Dotmatics Suite and also to exchange HELM-format data with other HELM-compliant systems. Additionally, Dotmatics’ analysis and visualization application, Vortex, reads HELM notation and from this generates oligomeric representations, allowing advanced analytical techniques to be applied directly to HELM-represented entities.
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