The HELM Antibody Editor allows the user to visualise and manipulate antibody structures.
It It includes many features, but the ability to detect domains and add structural features such as Cys-Cys bonds is central.
**New** HAbE2
HAbE2 is now available in GitHubwas released to GitHub in January 2018. Many thanks again to Roche who have continued to develop the antibody editor and have donated their efforts to the open source community.
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Key new features include:
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MonomerDesigner: ADCDesigner Domain Protease Reaction Sortase Coupling Biotinylation Domain Protease Reaction Sortase Coupling Biotinylation |
Getting started
All about HAbEThe following documents provide an overview of the antibody editor and the functionality available.
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- Compiled code can be found in the release folder in GitHub
Technical information
How to connect to the domain / mutation / rule libraries when located in a database
Custom Master Libraries in HAbE v2.pdf
How to write plugins e.g. to store the antibody constructs in databases instead of XML files
How to write plugins for HAbE v2.pdf
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HELM is an open source project released under the MIT license. However it HAbE2 currently has some dependencies one dependency on third party tools.
- HELM Editor HAbE2 requires yFiles for Java version 2.6 or higher and GraphML extension from yWorks. If you wish to use the compiled software directly there is no need to buy a licence. If you wish to develop the software for your own use, trial versions of such libraries can be downloaded from yWorks at www.yworks.com. You need to update the ant build file with regard to yfiles.dir and jar file names before compiling and running the project.
The HELM Toolkit requires MarvinBeans version 5.0 or higher from ChemAxon. A copy of the required library (MarvinBeans-5.0.jar) is included for your convenience. ChemAxon has graciously agreed to provide a royalty-free license for the utilization of MarvinBeans directly through the HELM editor and notation toolkit (specifically for operations pertaining to the chemical representation of HELM monomers and macromolecules.) Please contact Cassell Essell (cessell@chemaxon.com) to obtain this license. Utilization of the MarvinBeans library outside of the aforementioned scope and beyond a trial basis requires the procurement of a regular MarvinBeans license.
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Case Study
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