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Documents and articles of interest to the team

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    • References / Articles (weblink etc.)

    ArticleNotes / Comments
    https://theconversation.com/gut-microbes-may-affect-heart-disease-risk-new-research-94552(Christy)

    (Christy) Emma Allen Vercoe ("Poopy lab" expert

    TED talk

    https://www.scientificamerican.com/article/a-trip-to-ldquo-the-poopy-lab-rdquo-in-the-interest-of-drug-development/(Christy) Article on Emma Allen Vercoe and her "Poopy lab"
    https://hmpdacc.org/

    NIH Human Microbiome project, 2 projects:

    1. https://hmpdacc.org/hmp/ (5 major body site, using meta genomic shogun sequencing)
    2. https://hmpdacc.org/ihmp/ (three (pregnancy, IBS, type 2 diabetes onset) cohorts using multiple 'comics technologies)
    https://labiotech.eu/microbiome-research-review/

    Overview: where is microbiome heading in our industry? Themes:

    • 800+ clinical trials in this space
    • Market potential: $3.2Bn by 2024
    • Areas of focus
      • Mapping microbial genes
      • Oncology potential
      • microbiome based therapeutics
      • microbiota transplantation
      • Drugs targeting microbiota
      • Using bacteriophages
      • CRISPR/Cas9 cuttign bacteria DNA
      • Bioengineering bacteria to produce drugs in the gut
    • What's on the horizon?
      • Microbiome diagnostics / kits
      • Start of pharma investment (e.g J&J and Vedanta
    • Challenges:
      • No established FDA protocols for the microbiome
    https://www.nature.com/articles/d41586-018-05208-8

    Influence of microbiota in stomach on whether a cancer drug will work or not.

    Examples:

    Merck: faecal microbiome transplant to see if can switch non-responders to a drug treatment to a successful outcome

    Challenges / Oportunities:

    "The researchers looked at people with cancer from France and the United States, so diet could account for some of the differences, Wargo says. But variations in sample collection, data analysis and statistical methods could also have skewed the results, says Joël Doré, a biologist at the French National Institute for Agricultural Research in Paris who in 2011 helped to launch the International Human Microbiome Standards (IHMS) project with the aim of improving data reproducibility in microbiome research."

    "Wargo says that the community should standardize its approaches for collecting samples and doing analyses, as well as for validating studies in larger groups of patients."




    Contacts

    Contact / CommunityNotes
    http://www.nofone.org/microbiome

    (Christy) Autism research group (including Emma Allen Vercoe) one of their research areas is the microbiome as this page details.

    The key point of this group is that they are trying to encourage and initiate more funding for studies in this area. So research is still limited.

    http://www.translationalmicrobiome.org/Translational Microbiome Research forum
    http://www.microbiome-standards.org/Standards group (EMBL included) - primarily universities

    Organisations and their interest in this space

    OrganisationInterest in microbiome

    Texas Medical Center Biodesign see file in list above (                         TMC Microbriom Startup intro.pdf)


    		(Christy) - “start-up” - got an intro to these guys through Tim Hoctor (who incidentally introduced them, I believe, to Alan Lewis).   See attached document and at end list of folks/advisors.


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